Who will we Be?

OVER THE LAST 100,000 YEARS, OUR SPECIES HAS BEEN ON QUITE A RIDE.

WE'VE GONE FROM PRIMITIVE HUNTER-GATHERERS POKING AROUND FOR SCRAPS TO A WORLD-CONQUERING, CITY-DWELLING, HYPERCONNECTED SUPER SPECIES, AND IT'S ALL THANKS TO THE 3 POUNDS OF WET BIOLOGICAL MATERIAL STORED UP HERE.

WE LIVE SURROUNDED BY OUR INVENTIONS.

WE HAVE THE MEANS TO TRAVEL, TO MAKE, TO COMMUNICATE, TO BUILD.

WHAT I FIND INCREDIBLE IS THAT ALL OF THIS WAS BUILT WITH THE SAME NEURAL MATERIAL THAT OUR ANCESTORS USED TO HUNT AND TO BUILD PRIMITIVE TOOLS.

THE GENIUS OF MOTHER NATURE AND THE SECRET TO HER SUCCESS WAS TO BUILD A BRAIN THAT COULD INNOVATE TO MAKE THE JOURNEY FROM PRIMITIVE MAN TO THIS IN A VERY SHORT AMOUNT OF TIME.

I WANT TO EXPLORE WHAT IT IS ABOUT THE BRAIN THAT'S MADE THIS JOURNEY POSSIBLE.

IF WE CAN UNDERSTAND HOW IT WORKS, THEN MAYBE WE CAN DIRECT ITS POWER IN NEW WAYS AND OPEN A NEW CHAPTER IN THE HUMAN STORY.

SO WHAT'S NEXT FOR OUR BRAINS?

WHAT DO THE NEXT 1,000 YEARS HAVE IN STORE FOR US, AND IN THE FAR FUTURE, WHAT IS THE HUMAN RACE GOING TO LOOK LIKE?

WHAT WILL WE BE CAPABLE OF?

THIS IS A JOURNEY INTO WHO WE MIGHT BECOME.

WE'LL LOOK AT HOW WE CAN USE OUR BRAINS TO CONTROL NEW KINDS OF BODIES... [WHIRRING] HOW OUR SENSORY EXPERIENCE CAN BE EXPANDED TO NEW HORIZONS.

WE'LL LOOK AT HOW WE MIGHT ONE DAY SEPARATE OUR MINDS FROM OUR PHYSICAL SELVES, EVEN POSSIBLY OVERCOME DEATH.

ANNOUNCER: "THE BRAIN WITH DAVID EAGLEMAN" ANNOUNCER: "THE BRAIN WITH DAVID EAGLEMAN" THE HUMAN BODY-- IT'S A MASTERPIECE OF COMPLEXITY AND BEAUTY.

IT'S A SYMPHONY OF 40 TRILLION CELLS, ALL OPERATING IN CONCERT, AND IT'S ALL ORCHESTRATED BY THE 3-POUND ORGAN WE CALL THE BRAIN.

SENSORY INFORMATION FLOODS IN.

DECISIONS ARE MADE.

RESPONSES ARE FORMULATED.

THE BRAIN SENDS OUT COMMANDS, AND THE BODY MOVES INTO ACTION, BUT WHAT IF THE BRAIN COULD DO MORE, HANDLE MORE?

WHAT IF THERE WERE OTHER WAYS FOR IT TO OPERATE?

WE'RE HEADING FOR A FUNDAMENTAL CHANGE IN THE RELATIONSHIP BETWEEN THE BODY, THE BRAIN, AND THE OUTSIDE WORLD.

WE'RE MARRYING OUR BIOLOGY WITH OUR TECHNOLOGY, AND THAT'S POISED TO TRANSFORM WHO WE WILL BE.

THIS IS ALL POSSIBLE, THANKS TO A SPECIAL PROPERTY OF THE BRAIN CALLED PLASTICITY.

IT'S BEST ILLUSTRATED THROUGH A REMARKABLE STORY.

MEET CAMERON MOTT.

IN THIS HOME MOVIE, SHE'S 4 YEARS OLD.

♪ I'M A PRINCESS GIRL ALL DAY ♪ ♪ A PRINCESS GIRL, PRIN-- ♪ I'M A PRINCESS GIRL.

EAGLEMAN, VOICE-OVER: ONE DAY, CAMERON SUDDENLY STARTED HAVING SEIZURES.

OH!

OOH... WOMAN, VOICE-OVER: THE REALLY BIG ISSUE WAS THAT CAMERON'S SEIZURES WERE DROP SEIZURES WHERE SHE WOULD FALL DOWN TO THE FLOOR VERY QUICKLY, AND THEY WERE VERY AGGRESSIVE.

WOMAN: CAMERON?

OH!

WHOOPSY.

EAGLEMAN, VOICE-OVER: SHE WAS DIAGNOSED WITH RASMUSSEN'S SYNDROME, AN INFLAMMATORY DISEASE THAT ATTACKS THE BRAIN.

IT CAUSES PARALYSIS AND, ULTIMATELY, DEATH.

TO SAVE CAMERON'S LIFE, HER PHYSICIANS PROPOSED A RADICAL SOLUTION.

THEY WOULD REMOVE THE DISEASED PART OF HER BRAIN.

LITTLE HARDER.

MAN, VOICE-OVER: THE PROCEDURE ITSELF IS PROBABLY THE MOST DRASTIC SURGICAL PROCEDURE THAT CAN BE DONE IN NEUROSURGERY.

YOU KNOW, IT'S NOT A SIMPLE OPERATION.

THERE ARE MAN-- ON A SCALE OF 1 TO 10, 10 BEING ONE OF THE MORE DIFFICULT OPERATIONS THAT WE WOULD TYPICALLY PERFORM IN NEUROSURGERY, I'D SAY IT'S A 10.

EAGLEMAN, VOICE-OVER: SEEING NO OTHER OPTION, CAMERON'S PARENTS CONSENTED.

THE REAL RISK IN THE SURGERY IS NOT WHAT HAPPENS IF WE DO THE SURGERY.

THE QUESTION IS, WHAT HAPPENS TO THIS PERSON IF WE DON'T DO THE SURGERY?

EAGLEMAN, VOICE-OVER: THE ISSUE WAS THAT AN ENTIRE HALF OF CAMERON'S BRAIN HAD BEEN AFFECTED.

WOMAN, VOICE-OVER: OUR BIGGEST CONCERN WAS, WOULD SHE SURVIVE?

WOULD THERE BE SOME COMPLICATION?

UM, WOULD WE GO THROUGH ALL OF THIS AND THEN STILL HAVE SEIZURES AT THE END?

THIS IS CAMERON'S PREOPERATIVE SCAN.

THIS IS THE MATERIAL THAT UNDERPINS HER INTELLECT AND HER EMOTION AND HER SENSE OF HUMOR, WHO SHE IS.

IN THIS SCAN, THE EMPTY SPACE IS WHERE HALF OF HER BRAIN HAS BEEN REMOVED.

NO ONE COULD BE SURE HOW THE LOSS OF THAT MUCH BRAIN TISSUE WOULD AFFECT CAMERON.

WHAT WOULD SHE LOSE?

COULD SHE BE LIKE OTHER CHILDREN?

THIS IS CAMERON 7 YEARS ON.

SHE'S SEIZURE-FREE... AND, MORE IMPORTANTLY, BEYOND A SLIGHT WEAKNESS ON ONE SIDE, SHE BETRAYS NO SIGN OF THE ORDEAL THAT SHE WENT THROUGH.

MOTT: I LIKE TO RUN A LOT AND DO DIFFERENT TYPES OF STUFF OUTSIDE.

I LOVE MATH.

GIVE ME--GIVE ME 3 QUIZZES TO DO, AND I'LL DO IT.

OK. LET IT GO.

JUST IMAGINE TAKING YOUR LAPTOP AND TEARING OUT HALF THE MOTHERBOARD AND EXPECTING IT STILL TO FUNCTION.

IT WOULD NEVER WORK WITH A COMPUTER, BUT IT CAN WORK WITH A YOUNG BRAIN... AND THAT HAS DRAMATIC IMPLICATIONS.

WE USED TO THINK OF THE BRAIN AS A FIXED SYSTEM WITH DIFFERENT PARTS DEDICATED TO SPECIFIC JOBS, LIKE SEEING OR DECIDING OR MOVING, BUT NO REGION WORKS IN ISOLATION.

THE BRAIN IS A VAST, DYNAMIC, INTERCONNECTED NETWORK THAT'S ALWAYS CHANGING.

INSTEAD OF HARDWIRED, I LIKE TO THINK OF THE BRAIN AS LIVE-WIRED, AND THAT FLEXIBILITY OF THE BRAIN OPENS UP NEW POSSIBILITIES FOR OUR FUTURE.

IT COULD BE ARGUED THAT THIS FUTURE HAS BEEN WITH US SINCE THE 1970s IN THE FORM OF A SIMPLE PIECE OF TECHNOLOGY.

THIS IS A COCHLEAR IMPLANT, AND IT CAN GIVE HEARING TO DEAF PEOPLE.

IT PICKS UP SOUNDS AND CONVERTS THEM TO ELECTRICAL SIGNALS THAT PLUG DIRECTLY INTO THE CELLS OF THE INNER EAR.

NOW, WHEN IT WAS FIRST INTRODUCED, RESEARCHERS DIDN'T THINK IT WAS GOING TO WORK BECAUSE BIOLOGY IS WIRED UP WITH SUCH PRECISION AND SPECIFICITY AND THIS JUST TAKES CRUDE SIGNALS AND SHOVES THEM INTO THE BRAIN IN A WAY THAT THE BRAIN'S NOT EXPECTING.

THE COCHLEAR IMPLANT REPRESENTS A MARRIAGE BETWEEN METAL ELECTRODES AND BIOLOGICAL CELLS, AND YET IT WORKS.

AROUND THE WORLD, ALMOST A QUARTER-MILLION PEOPLE HAVE HAD THE CHANCE TO HEAR FOR THE FIRST TIME, THANKS TO THESE IMPLANTS.

WOW.

HA HA HA!

EAGLEMAN, VOICE-OVER: HERE'S HOW.

WHETHER IT COMES FROM YOUR EARS OR YOUR EYES OR A TOUCH ON YOUR SKIN, ALL THE INFORMATION THAT ENTERS YOUR BRAIN IS CONVERTED INTO THE SAME STUFF-- ELECTROCHEMICAL SIGNALS.

THESE ARE THE COMMON CURRENCY OF THE BRAIN.

WHEN THE IMPLANT PRODUCES THESE SIGNALS, HOWEVER CRUDELY, THE BRAIN FINDS A WAY TO MAKE SENSE OF THEM.

IT HUNTS FOR PATTERNS... CROSS-REFERENCING WITH OTHER SENSES.

AT FIRST, THE SIGNALS ARE UNINTELLIGIBLE, BUT SOON, MEANING EMERGES.

COCHLEAR IMPLANTS REVEAL SOMETHING AMAZING ABOUT THE BRAIN, WHICH IS, WHATEVER SIGNALS YOU FEED INTO IT, THE BRAIN WILL FIGURE OUT HOW TO EXTRACT SOMETHING USEFUL OUT OF THAT.

AS LONG AS THE DATA COMING IN HAS A STRUCTURE THAT MAPS ONTO THE OUTSIDE WORLD, THE BRAIN WILL FIGURE OUT HOW TO DECODE IT, AND THIS TURNS OUT TO BE ONE OF NATURE'S GREATEST TRICKS, AND NOW THAT WE KNOW ABOUT IT, IT OPENS UP A WORLD OF POSSIBILITIES.

WHY RESTRICT OURSELVES TO TRYING TO REPLACE LOST OR DAMAGED SENSES?

THERE MUST BE WAYS FOR US TO ENHANCE OR ADD TO THE SENSES THAT WE ALREADY HAVE.

IN MY LABORATORY, WE'VE CREATED THIS VEST.

IT TURNS SOUND INTO PATTERNS OF VIBRATION THAT ARE FELT ON THE SKIN OF THE TORSO.

THE IDEA IS THAT, GIVEN ENOUGH TIME, THE WEARER'S BRAIN WILL LEARN TO AUTOMATICALLY DECODE THESE VIBRATIONS.

THEY'LL INSTINCTIVELY FEEL AND UNDERSTAND INFORMATION.

THIS IS THE ALIEN LANGUAGE GAME, SO YOU'RE GONNA FEEL A WORD PRESENTED TO YOU AS A PATTERN OF VIBRATION ON YOUR TORSO.

THROUGH TIME, YOU'RE GOING TO GET BETTER AND BETTER AT THIS AS YOUR BRAIN STARTS DECODING HOW THESE INPUTS MAPS ONTO WORDS THAT YOU KNOW, AND YOUR JOB IS JUST TO FIGURE OUT WHAT THE LANGUAGE OF THE VEST IS.

I CAN FEEL THE VIBRATIONS ON MY BODY.

IT MAKES NO SENSE TO ME.

THEY'RE JUST RANDOM.

I'M AWARE THAT MAYBE ONE IN THE LEFT SHOULDER, RIGHT SHOULDER, LOWER BACK... [TROLLEY BELL RINGS] EAGLEMAN, VOICE-OVER: ONE OF MY LAB MEMBERS, JOSHUA, WORE THE VEST AS HE WENT ABOUT HIS DAY.

AN APP SENDS A PATTERN OF VIBRATIONS TO HIS TORSO.

HE GUESSES WHAT WORD THAT PATTERN REPRESENTS, AND HE'S TOLD WHETHER HE'S RIGHT OR WRONG.

JOSHUA, VOICE-OVER: FOR THE FIRST WEEK OR SO, I MEAN, IT'S JUST TOTAL NONSENSE TO TRY TO FIGURE OUT WHICH WORD WAS JUST PROJECTED ONTO ME, BUT AS TIME HAS GONE BY, I AM ABLE TO, THROUGH SOME PROCESS, DISTINGUISH THEM.

EAGLEMAN, VOICE-OVER: IT SEEMS STRANGE THAT YOU COULD UNDERSTAND INFORMATION THROUGH YOUR TORSO, BUT THAT'S THE SURPRISE.

IT DOESN'T MATTER HOW SIGNALS FIND THEIR WAY TO THE BRAIN.

WE HAVE THESE PERIPHERAL SENSES THAT WE PLUG IN, BUT HERE'S THE THING.

OUR EYES, OUR NOSE, OUR MOUTH-- THESE ARE JUST WHAT WE INHERIT FROM OUR EVOLUTIONARY PAST.

IT'S WHAT WE COME TO THE TABLE WITH, BUT WE DON'T HAVE TO STICK WITH IT BECAUSE IT MIGHT BE POSSIBLE THAT WE COULD PLUG SOME SENSORY CHANNEL INTO AN UNUSUAL PORT INTO THE BRAIN AND THE BRAIN WILL JUST FIGURE IT OUT, AND IT MAY BE THAT IN THE NEAR FUTURE, WE CAN INVENT NEW SORTS OF SENSORY DEVICES AND PLUG THEM DIRECTLY INTO THE BRAIN.

IN THEORY, THERE'S NO LIMIT TO THE NEW SENSORY EXPANSION THAT WE CAN CREATE.

SO JUST IMAGINE IF WE COULD FEED IN AN INPUT OF REAL-TIME WEATHER DATA SO YOU COULD FEEL IF IT'S RAINING 100 MILES AWAY OR IF IT'S GONNA SNOW TOMORROW... [THUNDER] OR IMAGINE FEEDING IN REAL-TIME STOCK DATA AND DEVELOPING AN INTUITIVE SENSE OF HOW THE MARKETS WERE MOVING.

YOU'D BE PLUGGED INTO THE GLOBAL ECONOMY.

BECAUSE OF THE BRAIN'S CAPACITY TO TAKE ON NEW INPUTS, WE SHOULD BE ABLE TO EXPAND THE EXPERIENCE OF BEING HUMAN.

WE COULD ENJOY THINGS THAT WOULDN'T BE POSSIBLE WITH THE TRADITIONAL SENSES WE ARRIVE WITH.

IT MAY BE THAT THE EVOLUTION OF OUR TECHNOLOGY, RATHER THAN OUR BIOLOGY, IS WHAT GUIDES THE JOURNEY OF OUR SPECIES FROM HERE ON OUT.

AS WE MOVE INTO THE FUTURE, WE'LL INCREASINGLY DESIGN OUR OWN PORTALS ON THE WORLD.

AS FAR AS WE CAN TELL, THERE'S NO LIMIT IN WHAT THE BRAIN CAN INCORPORATE.

INSTEAD, WE NOW HAVE THE TOOLS TO SHAPE OUR OWN SENSORY EXPERIENCES, TO WIDEN OUR SMALL WINDOWS ON REALITY.

EAGLEMAN, VOICE-OVER: NOW, HOW WE SENSE THE WORLD, THAT'S ONLY HALF THE STORY.

THE OTHER HALF IS HOW WE INTERACT WITH IT.

WHAT IF WE COULD USE THE BRAIN'S FLEXIBILITY TO CHANGE OUR PHYSICAL BODIES?

THIS IS JAN SCHEUERMANN.

BECAUSE OF A RARE GENETIC DISEASE, THE SPINAL CORD NERVES THAT CONNECT HER BRAIN TO HER MUSCLES HAVE DETERIORATED.

SCHEUERMANN, VOICE-OVER: I CAN'T MOVE ANYTHING BELOW MY NECK.

WHERE THE STEM OF MY BRAIN MEETS MY SPINAL CORD, THERE'S SOME DETERIORATION THERE, AND THE SIGNALS AREN'T GETTING THROUGH, SO MY BRAIN IS SAYING, "LIFT UP," TO MY ARM, AND MY ARM'S SAYING, "I CAN'T HEAR YOU."

EAGLEMAN, VOICE-OVER: NOW JAN'S PARTICIPATING IN A TRAILBLAZING EXPERIMENT-- PART NEUROSURGERY, PART ROBOTICS.

TWO ELECTRODE ARRAYS IMPLANTED INTO HER BRAIN PROVIDE A LINK FROM HER MOTOR CORTEX TO THIS-- THE WORLD'S MOST ADVANCED ROBOTIC ARM.

SCHEUERMANN: OK. UP, DOWN.

EAGLEMAN, VOICE-OVER: ITS FINGERS CAN CURL AND UNCURL.

IT CAN ROLL.

THE WRIST CAN FLEX.

JAN CAN CONTROL IT JUST BY THINKING ABOUT IT.

RIGHT... AND GRASP.

EAGLEMAN, VOICE-OVER: THOUGH SHE SPEAKS THE COMMANDS OUT LOUD, SHE HAS NO NEED TO.

THERE'S A DIRECT PHYSICAL LINK BETWEEN THE ARM AND HER BRAIN.

DOWN.

EAGLEMAN, VOICE-OVER: AN ARM NORMALLY MOVES BECAUSE OF A STORM OF ACTIVITY IN THE MOTOR CORTEX.

FROM THERE, THE SIGNALS TRAVEL DOWN THE SPINAL CORD TO THE MUSCLES OF THE ARM.

IN JAN'S CASE, ELECTRODES EAVESDROP ON THE CORTICAL SIGNALS DIRECTLY AND REDIRECT THOSE TO HECTOR, HER NEW ARM.

SCHEUERMANN, VOICE-OVER: LIKE RIDING A BICYCLE, THE BRAIN DOESN'T FORGET HOW TO MOVE THE ARM, EVEN THOUGH IT HASN'T MOVED IN--IN 10 YEARS.

EAGLEMAN, VOICE-OVER: WITH PRACTICE, THIS RELATIONSHIP WILL BECOME FULLY UNCONSCIOUS.

SHE'LL BE ABLE TO MOVE HECTOR AUTOMATICALLY WITHOUT THINKING ABOUT IT, JUST AS WE DO WITH OUR BIOLOGICAL LIMBS.

SCHEUERMANN: OH, IT FEELS VERY GOOD TO BE ABLE TO SHAKE HANDS AND FIST-BUMP AND INTERACT.

IT'S SO VERY LIFE-AFFIRMING TO ME TO BE ABLE TO REACH OUT AND TOUCH A PERSON.

EAGLEMAN, VOICE-OVER: JAN'S EXPERIENCE POINTS TO A FUTURE IN WHICH WE USE TECHNOLOGY TO ENHANCE AND EXTEND OUR BODIES, NOT ONLY REPLACING LIMBS OR ORGANS, BUT IMPROVING THEM, ELEVATING THEM FROM HUMAN FRAGILITY TO INDESTRUCTIBILITY.

HOLLYWOOD HAS OFTEN IMAGINED A PERSON WHO'S PART MACHINE.

WELL, THAT FANTASY IS FAST BECOMING REAL.

AS WE LEARN HOW TO TAKE ON NEW SENSORY EXPERIENCES AND CONTROL NEW KINDS OF BODIES, THAT'S GOING TO PROFOUNDLY CHANGE WHO WE ARE AS INDIVIDUALS, AND THAT'S BECAUSE OUR PHYSICALITY SETS THE TONE FOR HOW WE FEEL AND HOW WE THINK AND WHO WE ARE.

AT THIS MOMENT IN HISTORY, IT MAY BE THAT WE HAVE MORE IN COMMON WITH OUR STONE-AGE ANCESTORS THAN WE DO WITH OUR DESCENDANTS IN THE NEAR FUTURE.

WE'RE ALREADY BEGINNING TO EXTEND THE HUMAN BODY, BUT NO MATTER HOW MUCH WE ENHANCE OURSELVES, THERE'S SOMETHING WE NEED TO KEEP IN MIND.

OUR BODY IS MADE OF FLESH AND BONES.

IT'S GOING TO DETERIORATE AND DIE, BUT WHAT IF THE STUDY OF THE BRAIN COULD ADDRESS OUR MORTALITY?

WHAT IF IN THE FUTURE, WE DIDN'T HAVE TO DIE?

THERE WILL COME A MOMENT WHEN ALL OF YOUR NEURAL ACTIVITY WILL COME TO A HALT, AND THEN THE GLORIOUS EXPERIENCE OF BEING CONSCIOUS WILL COME TO AN END, AND IT DOESN'T MATTER WHO YOU KNOW OR WHAT YOU DO.

IT'S THE FATE OF ALL OF US.

IT'S THE FATE OF ALL LIFE, BUT ONLY HUMANS ARE SO UNUSUALLY INTELLIGENT THAT WE SUFFER OVER THIS.

WHEN SOMEONE DIES, THOSE WHO ARE LEFT GRIEVE.

THEY MOURN THE LOST RELATIONSHIP, BUT WITH EVERY DEATH, THERE'S ANOTHER LOSS.

EVERY BRAIN CONTAINS A LIFETIME OF INFORMATION, EXPERIENCES, KNOWLEDGE, WISDOM.

AT THE MOMENT OF DEATH, ALL THAT BECOMES LOST.

FRANCIS CRICK WAS ONE OF THE DISCOVERERS OF THE STRUCTURE OF DNA, AND HE WAS ALSO A FRIEND AND A MENTOR TO ME, AND WHEN HE DIED, I REMEMBERED THINKING ABOUT WHAT A WASTE IT WAS THAT HE WAS CREMATED AND THIS BRAIN OF ONE OF THE GREATS OF 20th-CENTURY BIOLOGY WAS GOING UP IN FLAMES BECAUSE EVEN AFTER A PERSON DIES, THERE'S A LOT OF INFORMATION ABOUT THEM STORED IN THE PHYSICAL STRUCTURE OF THEIR BRAIN, AND WE'RE REACHING A POINT IN NEUROSCIENCE WHERE IT BECOMES A POSSIBILITY THAT WE COULD PRESERVE A BRAIN AND READ OUT THE INFORMATION AND LIVE WITH THAT PERSON AGAIN.

BRAIN PRESERVATION IS A NEW FIELD.

IT'S CONTROVERSIAL, AND ITS PROMISE IS STILL UNPROVEN.

NONETHELESS, SOME PEOPLE ARE ACTIVELY EXPLORING THE POSSIBILITY.

HERE IN THE ARIZONA DESERT, THE RESEARCHERS AT THE ALCOR LIFE EXTENSION FOUNDATION BELIEVE THEY CAN GIVE THE DEAD A CHANCE TO LIVE AGAIN.

THIS FACILITY HOLDS THE REMAINS OF OVER 100 PEOPLE PRESERVED AT ULTRALOW TEMPERATURE.

IT'S RUN BY MAX MORE, WHO DESCRIBES HIMSELF AS A FUTUROLOGIST.

AS SOON AS LEGAL DEATH HAS BEEN DECLARED-- WHICH IS REALLY NOT BIOLOGICAL DEATH, BUT WE HAVE TO WAIT FOR THAT POINT LEGALLY-- WE CAN THEN MOVE THE PATIENT FROM THE BED INTO THE ICE BATH.

WE CAN ADD EXTERNAL ICE ON TOP.

WE RESTART RESPIRATION.

WE RESTART CIRCULATION BY DOING, ESSENTIALLY, MECHANICAL CPR, AND THEN WE ALSO ADMINISTER 16 DIFFERENT MEDICATIONS TO TRY AND PROTECT THE CELLS AS WE COOL DOWN.

EAGLEMAN, VOICE-OVER: EACH BODY IS SUBMERGED IN LIQUID NITROGEN, BRINGING ITS TEMPERATURE BELOW MINUS-300 DEGREES.

THIS PROCESS IS KNOWN AS CRYONIC SUSPENSION, AND IT DOESN'T REQUIRE A WHOLE BODY.

SOMETIMES A CLIENT CHOOSES TO PRESERVE ONLY THEIR HEAD AND BRAIN.

MORE: SO WHAT WE'LL DO IS, WE'LL DO THE NEUROSEPARATION SOMEWHERE DOWN HERE, A FEW VERTEBRAS DOWN.

WE'LL MOVE THE PATIENT'S CEPHALON INTO THE CEPHALON RING, WHERE THE HEAD IS ESSENTIALLY UPSIDE DOWN SO WE CAN EXCESS THE CAROTIDS, AND--JUST LIKE WITH THE WHOLE-BODY PROCEDURE, EXCEPT THERE, WE GO THROUGH THE CHEST-- HERE, WE'RE WASHING OUT THE BLOOD AND BODY FLUIDS UH, FROM THE BRAIN.

EAGLEMAN, VOICE-OVER: THE IDEA IS TO PERFECTLY PRESERVE A BODY INTO THE DISTANT FUTURE WITH THE HOPE THAT AN ADVANCED TECHNOLOGY NOT YET INVENTED WILL ALLOW FOR THAWING AND REANIMATION.

SO, MAX, TELL ME ABOUT THESE DEWARS.

ALL OUR PATIENTS ARE STORED IN THESE.

WE CALL THIS A BIGFOOT DEWAR.

UH, IT CONTAINS 4 WHOLE-BODY PATIENT, AS YOU CAN SEE FROM THIS 3D-PRINTED MODEL.

EACH OF THOSE GOES IN ALUMINUM POD THAT GIVES EXTRA PROTECTION, AND WE ALSO GET 5 NEUROPATIENTS IN THE CENTER COLUMN, SO THESE FILL UP WITH ABOUT 450 GALLONS OF LIQUID NITROGEN.

UH, THEY'RE NOT SEALED.

WE JUST HAVE A [INDISTINCT] CAP FLOATING ON THE TOP, AND WE TOP THESE UP ONCE A WEEK WITH LIQUID NITROGEN TO KEEP THEM FULL.

SO THERE ARE 9 PEOPLE IN HERE?

NOT IN EVERY ONE.

DEPENDS ON HOW MANY NEUROPATIENTS WE HAVE.

UH, THERE'S ACTUALLY ROOM FOR MORE NEUROPATIENTS, SO SOME OF THEM HAVE NEUROPATIENTS.

OTHERS DON'T, SO BETWEEN 4 AND 9.

EAGLEMAN, VOICE-OVER: ALCOR BEGAN 50 YEARS AGO.

CURRENTLY IT HOUSES 129 FROZEN RESIDENTS, AND THAT NUMBER CONTINUES TO GROW.

EAGLEMAN: SOME OF THE PICTURES SAY, "FIRST LIFE CYCLE-- 1927 TO 1996."

DO YOU SEE IT AS BEING A SECOND LIFE CYCLE?

WHAT WE'RE DOING IS, WE'RE REALLY JUST GIVING PEOPLE ANOTHER CHANCE AT LIFE.

JUST AS IF TODAY YOU WERE, YOU KNOW, IN YOUR 30s OR 40s, HAD A HEART ATTACK AND WE DID SOME EXPERIMENTAL SURGERY AND BROUGHT YOU BACK, YOU MIGHT HAVE SEVERAL DECADES MORE, BUT WE'RE TALKING SOMETHING A LITTLE BIT MORE RADICAL.

WE'RE TALKING ABOUT NOT JUST FOR ANOTHER 80 YEARS, BUT POTENTIALLY THOUSANDS OF YEARS, MAYBE LONGER.

EAGLEMAN, VOICE-OVER: THE PEOPLE IN THESE DEWARS HAVE TAKEN A LEAP OF FAITH INTO AN UNKNOWN FUTURE.

THERE'S NO GUARANTEE THAT THE TECHNOLOGY WILL EVER COME ALONG THAT ALLOWS THEM TO WAKE UP AGAIN...

SO PERHAPS THERE ARE OTHER WAYS TO ACCESS THE INFORMATION STORED IN A BRAIN NOT BY BRINGING A DECEASED PERSON BACK TO LIFE, BUT BY FINDING A WAY TO READ OUT THE DATA DIRECTLY.

THIS IS BOTH A PROMISING IDEA AND A MONUMENTAL CHALLENGE.

AT THE DEPARTMENT OF BRAIN AND COGNITIVE SCIENCES AT MIT, SEBASTIAN SEUNG IS AMONG THE FIRST PIONEERS OF THAT PROCESS.

HE'S ATTEMPTING TO MAP OUT THE INNUMERABLE CONNECTIONS THAT UNDERLIE A BRAIN'S FUNCTION.

THAT UNIMAGINABLY VAST NETWORK OF PATHWAYS AND LINKS IS CALLED THE CONNECTOME.

SEUNG: YOUR CONNECTOME IS UNIQUE.

IT'S ONE OF THE DEEPEST THEORIES IN NEUROSCIENCE THAT YOUR MEMORIES ARE STORED IN YOUR UNIQUE PATTERN OF CONNECTIONS.

I LIKE TO THINK OF IT AS A THEORY OF PERSONAL IDENTITY, WHAT MAKES YOU YOU.

EAGLEMAN, VOICE-OVER: THE AVERAGE HUMAN BRAIN HAS 86 BILLION NEURONS AND THOUSANDS OF TRILLIONS OF SYNAPTIC CONNECTIONS.

WHEN THE CONNECTOME IS FULLY WORKED OUT, IT WILL BE THE MOST COMPLEX WIRING DIAGRAM EVER CREATED.

SEUNG: IT'S VERY DIFFICULT TO MAP OUT CONNECTIVITY INSIDE THE BRAIN.

THERE'S ONLY ONE TECHNOLOGY RIGHT NOW WHICH PROMISES TO GIVE US ALL THE CONNECTIONS FROM A SINGLE PIECE OF BRAIN, AND THAT'S CALLED SERIAL ELECTRON MICROSCOPY.

EAGLEMAN, VOICE-OVER: SEUNG IS BEGINNING BY MAPPING A MOUSE BRAIN.

THE PROCESS STARTS WITH TAKING A PIECE OF BRAIN TISSUE AND SLICING IT.

SEUNG: IT'S A HIGH-TECH DELI SLICER FOR CUTTING VERY THIN SLICES OF BRAIN.

TO CUT REALLY THIN, YOU HAVE TO HAVE A VERY SHARP KNIFE.

THIS IS THE WORLD'S SHARPEST KNIFE, A DIAMOND KNIFE WHOSE BLADE IS HONED TO ATOMIC SHARPNESS.

YOU CAN SEE A METAL PART WHICH IS MOVING UP AND DOWN.

A PIECE OF BRAIN IS MOUNTED ON IT, AND THE BRAIN IS BEING MOVED BACK AND FORTH AGAINST A BLADE, SO SLICE AFTER SLICE OF BRAIN ARE FLOATING ONTO THE SURFACE OF WATER.

EACH SLICE PUSHES THE PREVIOUS SLICE FORWARD.

IN ORDER TO SEE THIS CUTTING PROCESS, A MICROSCOPE IS MOUNTED ON TOP OF THE ULTRAMICROTOME, AND IT PROJECTS AN IMAGE ONTO THIS COMPUTER SCREEN, WHERE WE SEE THE CUTTING HAPPENING.

THIS CONVEYOR BELT PRODUCES A TAPE, A VERY LONG TAPE WHICH IS KIND OF LIKE A MOVIE, EVERY FRAME OF WHICH IS A SLICE OF BRAIN.

EAGLEMAN, VOICE-OVER: ONCE THE BRAIN HAS BEEN ARRANGED IN THESE FILMLIKE STRIPS, EACH SAMPLE IS SUBDIVIDED INTO TINY AREAS WHICH ARE THEN SCANNED BY A POWERFUL ELECTRON MICROSCOPE.

THAT PROCESS PRODUCES THIS-- A SEGMENT OF BRAIN MAGNIFIED 100,000 TIMES.

AT THIS RESOLUTION, IT'S POSSIBLE TO SEE ALMOST EVERY FEATURE.

THESE SMALL, BLACK DOTS ARE DNA INSIDE AN INDIVIDUAL CELL.

THE NEXT STEP IS TO COMPILE THESE IMAGES.

BY STACKING THEM IN THE THOUSANDS, ONE ON TOP OF EACH OTHER, AND THEN TRACKING THE NEURONS THROUGH EACH IMAGE, IT'S POSSIBLE TO RECONSTRUCT THE EXACT WAY THAT THE NEURONS ARE CONNECTED, A 3-DIMENSIONAL MODEL OF THE CONNECTIVITY.

IT SHOULD BE POSSIBLE TO DO THIS WITH WHOLE HUMAN BRAIN SOMEDAY.

THE RESULT WOULD BE A MAP OF ALL THE WIRING THAT UNDERPINS A PERSON'S THOUGHTS, EXPERIENCES, AND BELIEFS.

THERE'S JUST ONE ISSUE.

SEUNG: IF YOU IMAGE AN ENTIRE HUMAN BRAIN WITH THIS RESOLUTION, IT WOULD BE A ZETTABYTE OF INFORMATION.

SOUNDS LIKE A DIRTY WORD, "ZETTABYTE."

YOU NEVER HEARD IT BEFORE.

IT'S NEVER SPOKEN IN POLITE COMPANY.

WELL, IT'S THE-- IT'S THE TOTAL DIGITAL CONTENT OF THE WORLD RIGHT NOW.

THAT'S, UH, HOW MUCH INFORMATION IT WOULD BE.

EAGLEMAN, VOICE-OVER: IT'S A DAUNTING FIGURE.

DOES IT MEAN THAT THE IDEA OF READING OUT A HUMAN BRAIN WILL ALWAYS REMAIN BEYOND OUR REACH?

WELL, EXPERIENCE SAYS THAT COMPUTING POWER ALONE SHOULDN'T BE A BARRIER FOR TOO MUCH LONGER.

THERE'S A COMMON OBSERVATION IN COMPUTING CALLED MOORE'S LAW.

IT STATES THAT PROCESSING POWER DOUBLES EVERY TWO YEARS.

IF THAT DOESN'T SOUND LIKE MUCH, THINK OF IT THIS WAY.

IT MEANS THAT COMPUTERS TODAY ARE A MILLION TIMES MORE POWERFUL THAN THEY WERE IN THE 1970s.

JUST 20 YEARS AGO, THIS SUPERCOMPUTER BEHIND ME WAS EQUIVALENT TO ALL THE COMPUTING POWER ON THE PLANET.

20 YEARS FROM NOW, IT'LL PROBABLY BE CONSIDERED A MODEST FORCE OF THE TYPE YOU MIGHT SHRINK DOWN AND WEAR ON YOUR BODY.

WE'RE IN AN ERA NOW WHERE WE'RE DEVELOPING TECHNOLOGIES THAT CAN STORE UNIMAGINABLE AMOUNTS OF DATA AND RUN GARGANTUAN SIMULATIONS, AND THIS IS WHERE OUR BIOLOGY IS ON A CRASH COURSE WITH OUR TECHNOLOGY.

SO LET'S SAY THE TIME WILL COME WHEN COMPUTER POWER ISN'T AN ISSUE.

THAT OPENS UP A NEW REALM OF POSSIBILITY.

SUPPOSE WE COULD MAKE A DIGITAL COPY OF THE BRAIN.

THEN NOT ONLY WE COULD READ IT OUT.

WE COULD MAKE IT RUN.

IN THE SAME WAY THAT COMPUTER SOFTWARE CAN RUN ON DIFFERENT HARDWARE, IT MAY BE THAT THE SOFTWARE OF THE MIND CAN RUN ON OTHER PLATFORMS.

IN OTHER WORDS, WHAT IF THERE'S NOTHING SPECIAL ABOUT THE BIOLOGICAL NEURONS THEMSELVES AND INSTEAD, IT'S ONLY HOW THEY CONNECT AND INTERACT THAT MAKES A PERSON WHO THEY ARE.

IF THAT PROVED TO BE CORRECT, IT WOULD FOLLOW THAT WE CAN EXIST DIGITALLY BY RUNNING OURSELVES AS A SIMULATION, AND THIS IS WHAT'S KNOWN AS THE COMPUTATIONAL HYPOTHESIS OF THE BRAIN.

THE IDEA IS THAT THE WET, BIOLOGICAL, GUSHY STUFF ISN'T THE IMPORTANT PART.

WHAT MATTERS ARE THE COMPUTATIONS THAT ARE RUNNING ON TOP.

THE IDEA IS THAT THE MIND IS NOT WHAT THE BRAIN IS.

IT'S WHAT THE BRAIN DOES.

IN THEORY, YOU MIGHT SWAP CELLS FOR CIRCUITS, OXYGEN FOR ELECTRICITY.

THE MEDIUM DOESN'T MATTER, PROVIDED ALL THE PIECES AND PARTS ARE CONNECTING AND INTERACTING IN THE SAME WAY.

ALL YOUR THOUGHTS, EMOTIONS, MEMORIES, YOUR WHOLE PERSONALITY WOULD STILL EMERGE.

THERE'D BE NO BIOLOGICAL BRAIN, BUT THERE'D STILL BE A FULLY FUNCTIONING VERSION OF YOU.

THIS SOUNDS LIKE SCIENCE FICTION, BUT A TEAM IN SWITZERLAND HAS BEGUN AN EXCEPTIONALLY AMBITIOUS PROJECT THAT TAKES THE FIRST STEPS DOWN THIS PATH.

THEY'RE ATTEMPTING TO BUILD A FULL WORKING SIMULATION OF A BRAIN.

IT'S CALLED THE BLUE BRAIN PROJECT.

SEAN HILL IS ONE OF THE MEMBERS OF THE TEAM.

EAGLEMAN: WHAT IS THE LONG-TERM GOAL HERE?

TO DELIVER BY 2023 A SOFTWARE AND HARDWARE INFRASTRUCTURE CAPABLE OF RUNNING A WHOLE HUMAN BRAIN SIMULATION.

IF WE WANT TO MOVE TOWARDS BEING ABLE TO SIMULATE AN ENTIRE HUMAN BRAIN, HOW DO WE KNOW WHAT ARE THE IMPORTANT THINGS TO CAPTURE-- THE STRUCTURE, THE CELLS, ALL THE WAY DOWN TO THE PROTEINS, THE MOLECULES?

HOW DO WE KNOW?

WE'RE WORKING AT SUBCELLULAR.

WE'RE WORKING AT CELLULAR.

WE'RE WORKING AT MICROCIRCUIT.

WE'RE WORKING AT BRAIN REGIONS OF MESOCIRCUITS, AND THEN WE HAVE WHOLE BRAIN BUT FOR VERY SIMPLIFIED NEURONS, SO OUR GOAL IS TO GET TO WHOLE BRAIN BUT WITH VERY DETAILED NEURONS.

EAGLEMAN, VOICE-OVER: AS A STARTING POINT, THEY'RE LOOKING AT RAT BRAINS.

THEY TAKE TINY SLICES OF BRAIN AND SUBJECT THEM TO MINUTE JOLTS OF ELECTRICAL CURRENT.

THAT MIMICS THE ACTIVITY OF THE LIVING BRAIN AND PROMPTS THE CELLS TO INTERACT.

EACH INTERACTION IS RECREATED ON THE PROJECT'S SUPERCOMPUTER AND THEN INTEGRATED INTO A LARGER MODEL WITH DATA FROM HUNDREDS OF OTHER LABS AROUND THE WORLD.

THE RESULT IS THIS ELECTRICAL STORM.

THIS IS THE BEST APPROXIMATION OF WHAT A VERY TINY FRACTION OF YOUR BRAIN IS DOING WHEN YOU'RE, SAY, JUST STARING INTO SPACE.

THE TOTAL ACTIVITY IN YOUR BRAIN IS HUNDREDS OF MILLIONS OF TIMES MORE THAN WHAT YOU'RE SEEING HERE, AND THIS TYPHOON OF ACTIVITY IS ROARING ALONG EVERY SECOND OF YOUR LIFE.

WE'RE NOT BUILDING ABSTRACT MODELS.

WE ACTUALLY TAKING DATA FROM LABORATORIES.

WE'RE EXTRACTING, UH, PROBABILITIES.

WE'RE EXTRACTING DISTRIBUTIONS FROM THAT TO BUILD A MUCH LARGER MODEL THAT IS BASED ON BIOLOGICAL DATA, NOT BASED ON THE ASSUMPTION OF HOW--HOW BIOLOGY WORKS, BUT ACTUALLY ON DATA THAT COMES OUT OF A BIOLABORATORY.

EAGLEMAN, VOICE-OVER: THE BLUE BRAIN TEAM HOPES TO ACHIEVE THEIR GOAL BY 2023-- A FULL WORKING SIMULATION OF A HUMAN BRAIN, AND THAT RAISES A QUESTION-- WHAT WILL THE FINISHED PRODUCT BE?

WILL IT BE A MIND?

WILL IT THINK?

WILL IT BE SELF-AWARE?

IF THE ANSWER IS YES AND A MIND CAN LIVE IN A COMPUTER, THEN DO WE HAVE TO COPY NATURE'S BIOLOGICAL BLUEPRINTS, OR MIGHT IT BE POSSIBLE TO PROGRAM A DIFFERENT KIND OF INTELLIGENCE, ONE OF OUR OWN INVENTION?

PEOPLE HAVE BEEN TRYING FOR A LONG TIME TO CREATE MACHINES THAT THINK.

THIS FIELD, CALLED ARTIFICIAL INTELLIGENCE, HAS BEEN AROUND SINCE AT LEAST THE 1950s.

THE PROBLEM HAS TURNED OUT TO BE UNEXPECTEDLY DIFFICULT, AND THIS SPEAKS TO THE EXTRAORDINARY ENIGMA OF HOW THE BRAIN DOES WHAT IT DOES... BECAUSE, WHILE WE'LL SOON HAVE CARS THAT DRIVE THEMSELVES AND IT'S ALMOST TWO DECADES SINCE A COMPUTER FIRST BEAT A CHESS GRAND MASTER, THE GOAL OF A TRULY SENTIENT MACHINE STILL WAITS TO BE ACHIEVED.

ONE OF THE LATEST ATTEMPTS TO CREATE AN ARTIFICIAL INTELLIGENCE CAN BE FOUND AT THE UNIVERSITY OF PLYMOUTH IN ENGLAND.

IT'S CALLED iCUB.

IT'S A HUMANOID ROBOT, AND IT'S DESIGNED TO LEARN AS A CHILD LEARNS.

TRADITIONALLY, ROBOTS ARE PREPROGRAMMED WITH EVERYTHING THEY NEED TO KNOW, BUT WHAT IF YOU COULD CREATE A ROBOT BY DEVELOPING IT THE WAY THAT A HUMAN INFANT GROWS?

iCUB IS ABOUT THE SIZE OF A TWO-YEAR-OLD.

IT HAS EYES AND EARS AND TOUCH SENSORS, AND THESE ALLOW IT TO INTERACT WITH THE WORLD AND LEARN FROM IT.

BABIES DON'T COME INTO THE WORLD KNOWING HOW TO SPEAK AND WALK, BUT THEY COME WITH CURIOSITY, AND THEY PAY ATTENTION, AND THEY IMITATE.

THEY USE THE WORLD THAT THEY'RE IN AS A TEXTBOOK SO THEY CAN LEARN BY EXAMPLE, SO WHAT IF YOU WANTED TO CREATE A ROBOT TO DO THE SAME THING?

WELL, YOU WOULD TAKE A CRUDE BRAIN SIMULATION, AND YOU'D GIVE IT A MECHANICAL BODY SO THAT IT COULD INTERACT WITH THE WORLD.

HELLO.

HELLO.

I'M iCUB.

THIS IS A RED BALL.

THIS IS A RED BALL.

THIS IS A YELLOW CUP.

YELLOW CUP.

EAGLEMAN, VOICE-OVER: THE AIM IS THAT WITH EACH INTERACTION, THE ROBOT CONTINUALLY ADDS TO ITS BASE OF KNOWLEDGE.

IT'S MAKING CONNECTIONS AND BUILDING A REPERTOIRE OF APPROPRIATE RESPONSES, AND, BECAUSE IT LOOKS AND SOUNDS A BIT LIKE A HUMAN, IT'S EASY TO BE CONVINCED THAT IT THINKS LIKE ONE.

WHERE IS THE YELLOW CUP?

WHERE IS THE RED BALL?

EAGLEMAN, VOICE-OVER: OFTEN, iCUB GETS IT WRONG.

THAT'S PART OF THE PROCESS... WHAT IS THIS?

I'M SORRY.

I DON'T KNOW WHAT THIS IS.

EAGLEMAN, VOICE-OVER: BUT THE MORE IT GETS IT WRONG, THE MORE YOU GET THE SENSE THERE'S NO REAL MIND BEHIND THE PROGRAM.

WHAT IS THIS?

I'M SORRY.

I DON'T KNOW WHAT THIS IS.

EAGLEMAN, VOICE-OVER: WHAT BECOMES CLEAR IS THAT iCUB IS PURELY MECHANICAL.

YOU CAN FEEL THAT IT'S RUN BY LINES OF CODE INSTEAD OF TRAINS OF THOUGHT, SO IT CAN SAY, "RED BALL," BUT DOES IT REALLY EXPERIENCE REDNESS OR THE CONCEPT OF ROUNDNESS?

DO COMPUTERS DO JUST WHAT THEY'RE PROGRAMMED TO DO, OR CAN IT EVER REALLY HAVE INTERNAL EXPERIENCE?

IN THE 1980s, THE PHILOSOPHER JOHN SEARLE WAS CHEWING ON THIS PROBLEM, AND HE CAME UP WITH A THOUGHT EXPERIMENT THAT GETS RIGHT AT THE HEART OF IT, AND HE CALLED THIS THE CHINESE ROOM.

EAGLEMAN, VOICE-OVER: THE EXPERIMENT GOES LIKE THIS.

I'M LOCKED IN A ROOM.

OUTSIDE, THERE'S SOMEONE WHO ONLY COMMUNICATES IN CHINESE.

SHE WRITES OUT SOME QUESTIONS AND THEN POSTS THOSE TO ME IN THE ROOM.

NOW, I DON'T SPEAK CHINESE, BUT I DO HAVE THESE BOOKS, AND THEY GIVE ME INSTRUCTIONS ON EXACTLY WHAT TO DO WITH THESE SYMBOLS, SO I LOOK IN THE BOOK, AND--AND IF I CAN FIND A MATCH TO THE SYMBOLS, THEN THE BOOK TELLS ME EXACTLY HOW TO RESPOND, SO I CAN LOOK UP THIS RESPONSE.

THAT MATCHES, SO NOW I CAN POST THIS AS THE REPLY TO THE MESSAGE I RECEIVED.

EAGLEMAN, VOICE-OVER: WHEN OUR CHINESE SPEAKER RECEIVES THE MESSAGE, IT MAKES PERFECT SENSE TO HER.

[SPEAKING CHINESE] EAGLEMAN, VOICE-OVER: AS FAR AS SHE'S CONCERNED, WE'RE HAVING A CONVERSATION IN HER LANGUAGE.

JUST BY FOLLOWING A SET OF INSTRUCTIONS, I CAN CONVINCE SOMEBODY ON THE OUTSIDE THAT I SPEAK CHINESE, AND IF I HAVE A LARGE ENOUGH SET OF RESPONSE BOOKS, I CAN HAVE A CONVERSATION ABOUT ANYTHING, BUT HERE'S THE IMPORTANT PART.

I, THE OPERATOR, DO NOT UNDERSTAND CHINESE.

I CAN MANIPULATE SYMBOLS ALL DAY LONG, BUT NONE OF IT HAS ANY MEANING TO ME.

THE ARGUMENT GOES THAT THIS IS JUST WHAT HAPPENS INSIDE A COMPUTER.

NO MATTER HOW SENTIENT IT SEEMS, THE COMPUTER IS ONLY EVER FOLLOWING INSTRUCTIONS, MANIPULATING SYMBOLS.

NOW, NOT EVERYBODY AGREES WITH THIS INTERPRETATION OF THE CHINESE ROOM.

SOME PEOPLE POINT OUT THAT, ALTHOUGH THE OPERATOR DOESN'T UNDERSTAND CHINESE, THE SYSTEM AS A WHOLE, THE OPERATOR PLUS THE BOOKS, DOES UNDERSTAND CHINESE.

WHATEVER THE CORRECT INTERPRETATION, THE IMPORTANT THING IS THIS.

IT EXPOSES THE DIFFICULTY AND THE MYSTERY OF HOW PHYSICAL PIECES AND PARTS EVER COME TO EQUAL OUR EXPERIENCE OF BEING ALIVE IN THE WORLD.

WITH EVERY ATTEMPT TO SIMULATE OR CREATE SUBJECTIVE EXPERIENCE, WE'RE CONFRONTED WITH ONE OF THE GREATEST MYSTERIES OF NEUROSCIENCE.

EVERY BRAIN CELL IS JUST A CELL... RUNNING ITS BASIC OPERATIONS, FOLLOWING ITS LOCAL RULES.

HOW DO BILLIONS OF THESE ADD UP TO THE FEELING OF ME?

IF WE WANT TO SEE HOW SIMPLE PARTS CAN GIVE RISE TO SOMETHING BIGGER, ONE CAN LOOK TO THE NATURAL WORLD.

THE HOUSTON ZOO IS HOME TO A LARGE COLONY OF LEAF CUTTER ANTS.

INDIVIDUALLY, EACH ANT BEHAVES SIMPLISTICALLY, BUT WHEN THESE ANTS WORK TOGETHER, THE COLONY IS LIKE A SUPER ORGANISM THAT ACCOMPLISHES SOMETHING MUCH GREATER.

MAN: ALL OF THESE ANTS HAVE A DIFFERENT JOB.

THERE ARE SOME THAT ARE REALLY, REALLY GOOD AT JUST CUTTING LEAVES, OTHERS THAT ARE GOOD AT CARRYING LEAVES, AND THEN OTHERS THAT DO OTHER FUNCTIONS WITHIN THE GROUP.

THEY'RE INDEPENDENT, BUT THEY ALL WORK TOWARDS A COMMON CAUSE, SO THEY'RE ALL COMING OUT DOING WHAT THEIR JOB IS TO DO FOR THE GOOD OF THE WHOLE COLONY.

SO DO THESE ANTS COMMUNICATE BY CHEMICAL SIGNALING?

YES.

THEY DO.

WHENEVER THEY FIND SOMETHING THAT IS, YOU KNOW, A GREAT LEAF FOR THEM TO CUT OR FRUIT OR VEGETABLES, UH, WHEN ONE ANT GOES AND FINDS THAT, THEY WILL LAY THAT SIGNAL, AND THEN THE REST WILL JUST FOLLOW IT, AND IT BECOMES A VERY STRAIGHT LINE.

INSTEAD OF THEM BRANCHING OUT, GOING DIFFERENT DIRECTIONS TO GET TO THE SAME THING, THEY ALL FOLLOW THE-- THE CHEMICAL SIGNAL.

SO WHAT HAPPENS IF ONE OF THESE ANTS IS JUST OFF BY HIMSELF?

SO IF WE WERE TO GET THIS GUY, THIS IS A BIGGER ANT HERE.

YEAH.

POOR GUY.

HE'S JUST-- HE'S JUST RUNNING...

GOING AROUND IN CIRCLES.

SPINNING IN CIRCLES.

YEAH.

HE'S NOT GETTING THAT SIGNAL, THAT CHEMICAL SIGNAL, BACK THAT, "YOU ARE GOING IN THE RIGHT DIRECTIONS."

EAGLEMAN, VOICE-OVER: THIS ANT CAN'T FUNCTION OUTSIDE THE NETWORK OF LOCAL SIGNALS BECAUSE HE NEEDS THOSE TO TELL HIM WHAT DO.

PUT HIM BACK INTO THE NETWORK, AND HE DOES JUST WHAT'S NEEDED TO SERVE THE GREATER PURPOSE.

THE SCOUT ANTS ONLY WORRY ABOUT WHERE TO FIND THE BEST PLANTS.

THE LEAF CUTTERS DO THE CUTTING.

THE CARRIERS KNOW WHICH PARTS TO BRING BACK TO THE NEST, AND THERE, INSIDE, OTHER ANTS BUILD, TEND, HARVEST, MATE.

IT'S AN ENTIRE SYSTEM REGULATED BY LOCAL SIGNALING BETWEEN THEM.

IN ALL OF THIS, NO ONE ANT SEES THE BIG PICTURE ABOUT THE AGRICULTURAL SOCIETY THEY'VE CREATED, AND IT DOESN'T MATTER.

THE POWER OF THE COLONY EMERGES FROM THE LOCAL INTERACTIONS BETWEEN THE ANTS.

PUT ENOUGH ANTS TOGETHER, AND, BANG, YOU GET A SUPERORGANISM WITH SOPHISTICATED PROPERTIES THAT DON'T BELONG TO ANY OF THE PARTS, AND THIS IS THE CONCEPT OF EMERGENT PROPERTIES.

PUT ENOUGH SIMPLE UNITS TOGETHER AND HAVE THEM INTERACT IN THE RIGHT WAYS, AND SOMETHING LARGER EMERGES.

THE IDEA IS THAT SOMETHING LIKE THIS HAPPENS IN THE BRAIN.

A NEURON HAS CERTAIN PROPERTIES.

IT CAN GATHER CHEMICAL AND ELECTRICAL SIGNALS AND SPIT OUT SIGNALS TO OTHER NEURONS, BUT FUNDAMENTALLY, IT'S A CELL, LIKE TRILLIONS OF OTHERS IN THE HUMAN BODY.

IT SPENDS ITS LIFE EMBEDDED IN A NETWORK OF OTHER CELLS, AND, WHATEVER ITS FUNCTION, ALL IT DOES IS REACT TO LOCAL SIGNALS.

JUST LIKE THE ANT, A BRAIN CELL SPENDS ITS LIFE RUNNING ITS LOCAL PROGRAMS, BUT GET ENOUGH BRAIN CELLS TOGETHER INTERACTING IN THE RIGHT WAYS, AND THE MIND EMERGES.

THE CONCEPT OF EMERGENT PROPERTIES OFFERS A POSSIBLE WAY TO UNDERSTAND HOW THE VAST NEURAL POPULATIONS OF THE BRAIN MIGHT PRODUCE CONSCIOUSNESS, AND IT GIVES RISE TO A QUESTION-- COULD CONSCIOUSNESS EMERGE FROM ANYTHING THAT HAS LOTS OF INTERACTING PARTS?

COULD A CITY BE CONSCIOUS?

OR MAYBE IT'S NOT ENOUGH TO HAVE LOT OF SIMPLE PIECES INTERACTING.

MAYBE THE PARTS NEED TO INTERACT IN VERY SPECIFIC WAYS.

IF THAT'S TRUE, THEN WE MIGHT EXPECT TO FIND PARTICULAR SIGNATURES OF ACTIVITY IN NETWORKS THAT ARE CONSCIOUS.

AT THE UNIVERSITY OF WISCONSIN, GIULIO TONONI AND HIS TEAM ARE HUNTING FOR THOSE SIGNATURES.

THEY'RE FOCUSING ON THE TRANSITION TO CONSCIOUSNESS THAT HAPPENS IN THE BRAIN EVERY SINGLE DAY WHEN WE WAKE UP.

TONONI, VOICE-OVER: WHEN YOU WAKE UP IN THE MORNING FROM A DREAMLESS SLEEP, BEFORE, THERE WAS ABSOLUTELY NOTHING, AND THEN YOU'RE AWAKE, AND IN THE--THE SPACE OF A FEW SECONDS, THERE IS EVERYTHING-- COLORS, SOUNDS, PEOPLE, THOUGHTS, DESIRES, PLANS FOR THE DAY, AND, OF COURSE, THE WORLD AROUND YOU.

THAT IS CONSCIOUSNESS.

EAGLEMAN, VOICE-OVER: TONONI'S EXPERIMENTS USE TMS, TRANSCRANIAL MAGNETIC STIMULATION, TO MAKE SMALL, TARGETED DISRUPTIONS IN BRAIN ACTIVITY, AND THEY CAN DO THIS WHILE A PERSON IS AWAKE OR ASLEEP.

IN THE AWAKE BRAIN, AN ELECTRICAL PULSE MOVES OUTWARDS ACROSS THE CORTEX LIKE RIPPLES ON A POND, BUT IN THE SLEEPING BRAIN, ONLY NEARBY AREAS REACT.

THE RIPPLES HARDLY SPREAD.

TONONI, VOICE-OVER: WHEN YOU FALL INTO DREAMLESS SLEEP, SOMEHOW THE NEURONS ARE NOT ABLE TO TALK TO EACH OTHER.

WHAT WE ACTIVATE WITH TMS REMAINS VERY LOCAL.

IT REMAINS THERE.

IT DOESN'T TRAVEL ANYMORE.

EAGLEMAN, VOICE-OVER: THAT SPREAD OF ACTIVITY ACROSS THE WAKING BRAIN MAY BE A CLUE TO CONSCIOUSNESS.

WHILE DIFFERENT REGIONS OF THE BRAIN ARE INVESTED IN DIFFERENT TASKS, CONSCIOUSNESS SEEMS TO HAVE SOMETHING TO DO WITH INTEGRATING ACTIVITY ACROSS VAST BRAIN TERRITORIES, LINKING AREAS TO PRODUCE A SINGLE, UNIFIED EXPERIENCE.

TONONI, VOICE-OVER: YOU DON'T HAVE AN EXPERIENCE SPLIT IN TWO PIECES.

WHEN I SEE YOUR SHIRT, I DON'T SEE A SHAPE AND THE COLOR SEPARATED FROM EACH OTHER.

THEY ARE TOGETHER.

THEY ARE BOUND TOGETHER, SO EVERY EXPERIENCE IS ONE.

EAGLEMAN, VOICE-OVER: EVERY MOMENT OF EXPERIENCE IS A COMPOSITE CREATED FROM INNUMERABLE POSSIBILITIES.

I MIGHT BE FEELING THE HEAT OF THE DAY.

I MIGHT BE REMEMBERING AN EVENT FROM HIGH SCHOOL.

MY STOMACH MIGHT BE DIGESTING LUNCH.

I'M ALSO SEEING.

I'M HEARING.

MY BRAIN WILL CREATE MY SENSE OF SELF FROM ALL THESE DIFFERENT STRANDS.

HOW THE STRANDS ARE WOVEN TOGETHER IS STILL A MYSTERY, BUT TONONI BELIEVES THAT THE KEY TO CONSCIOUSNESS IS CONTAINED IN THESE PATTERNS OF INTERACTION.

HE ALSO BELIEVES THAT THIS KEY DOESN'T HAVE TO BELONG ONLY TO BIOLOGICAL CREATURES.

THAT DEFINITELY IS HOW IT EVOLVED, AND IT TAKES AN ORGANIZATION OF THAT KIND TO DO IT.

IT JUST NEEDS TO BE MADE THE RIGHT WAY.

EAGLEMAN, VOICE-OVER: BUILDING CONSCIOUSNESS ON ANOTHER MEDIUM IS STILL SQUARELY IN THE REALM OF SPECULATION.

IT COULD TURN OUT THAT THERE'S SOMETHING SPECIAL ABOUT NEURONS SO THAT ONLY A BIOLOGICAL BRAIN COULD PRODUCE CONSCIOUSNESS.

NONETHELESS, THIS IDEA OFFERS US A GLIMPSE OF ONE POSSIBLE FUTURE.

WITH POWERFUL ENOUGH COMPUTERS SIMULATING ALL THE INTERACTIONS OF A HUMAN BRAIN, WE COULD ONE DAY BECOME NONBIOLOGICAL BEINGS, AND THAT WOULD BE THE GREATEST LEAP IN THE HISTORY OF OUR SPECIES.

WE COULD LEAVE THESE BODIES BEHIND.

DIGITALLY, YOU COULD LIVE WHATEVER LIFE YOU WANTED WHEREVER YOU WANTED WITH A KIND OF IMMORTALITY ON OFFER.

WHILE THE STARS ARE FAR BEYOND THE REACH OF ANY FLESH-AND-BLOOD HUMAN LIFESPAN, YOU COULD BE UPLOADED AND SENT OFF TO EXPERIENCE OTHER SOLAR SYSTEMS... OR YOU COULD ENTER AN EXISTENCE IN A SIMULATED WORLD... ONE IN WHICH YOU FLEW... OR LIVED UNDERWATER OR LIVED A LIFE OF LUXURY.

MAYBE YOU COULD JOURNEY INTO A RECONSTRUCTED VERSION OF THE PAST.

WHEN WE IMAGINE SIMULATED LIFE, THE CHOICES ARE ENDLESS, AND THEY INCLUDE A STRANGE POSSIBILITY THAT WHAT WE'RE TALKING ABOUT IS SOMETHING THAT'S HAPPENING ALREADY RIGHT NOW.

THE SIMULATION COULD LOOK SOMETHING LIKE THIS, AND IT COULD BE THAT WE'RE ALREADY IN IT.

NOW, THAT IDEA MIGHT SEEM PREPOSTEROUS, BUT IT'S SURPRISINGLY DIFFICULT TO DISPROVE.

IT SEEMS HARD TO IMAGINE THAT ALL OF THIS COULD BE A SIMULATION, BUT WE ALREADY KNOW HOW EASILY WE CAN BE FOOLED.

EVERY NIGHT WHEN YOU GO TO SLEEP, YOU HAVE BIZARRE DREAMS, AND WHEN YOU'RE THERE, YOU BELIEVE THOSE WORLDS ENTIRELY.

THE FACT THAT YOU CAN BE SO FOOLED BY YOUR DREAMS IS SUFFICIENT REASON TO QUESTION WHAT YOU'RE EXPERIENCING RIGHT NOW.

THE PHILOSOPHER RENE DESCARTES WONDERED, "HOW CAN WE EVER KNOW WHETHER WHAT WE'RE EXPERIENCING IS REALITY?"

HE SAID, "HOW DO I KNOW I'M NOT JUST A BRAIN IN A VAT "THAT'S BEING STIMULATED IN JUST THE RIGHT WAYS "SO THAT I BELIEVE THAT I'M TOUCHING THE GROUND AND SEEING PEOPLE AND HEARING THEIR VOICES?"

AND HE REALIZED THERE'S NO WAY TO KNOW, BUT HE REALIZED SOMETHING ELSE, THAT THERE'S SOME ME AT THE CENTER OF ALL THIS TRYING TO FIGURE THIS OUT, SO EVEN IF I AM A BRAIN IN A SIMULATION, I'M THINKING ABOUT IT, AND, THEREFORE, I AM.

OVER THE COURSE OF THIS SERIES, WE'VE DISCOVERED JUST HOW COMPLEX AND REMARKABLE THE HUMAN BRAIN IS, HOW REALITY IS SOMETHING CONSTRUCTED INSIDE OUR HEADS, HOW WE'RE BUILT TO NEED OTHERS... HOW SO MUCH OF WHO WE ARE AND WHAT WE CHOSE TO DO IS GOVERNED BY FACTORS OUTSIDE OUR CONSCIOUS MINDS.

NOW IT SEEMS TO ME THAT WE STAND AT A MAJOR TURNING POINT, ONE WHERE WE MIGHT TAKE CONTROL OF OUR OWN DEVELOPMENT.

WE FACE A FUTURE OF UNCHARTED POSSIBILITIES IN WHICH OUR RELATIONSHIP WITH OUR OWN BODY, OUR RELATIONSHIP WITH THE WORLD, THE VERY BASIC NATURE OF WHO WE ARE IS SET TO BE TRANSFORMED.

FOR THOUSANDS OF GENERATIONS, HUMANS HAVE LIVED THE SAME LIFE CYCLE OVER AND OVER.

WE'RE BORN.

WE CONTROL A FRAGILE BODY.

WE EXPERIENCE A LIMITED REALITY, AND WE DIE, BUT SCIENCE AND TECHNOLOGY ARE GIVING US TOOLS TO TRANSCEND THAT EVOLUTIONARY STORY.

OUR BRAINS DON'T HAVE TO REMAIN AS WE'VE INHERITED THEM.

WE'RE CAPABLE OF EXTENDING OUR REALITY, OF INHABITING NEW BODIES, AND POSSIBLY SHEDDING OUR PHYSICAL FORMS ALTOGETHER.

OUR SPECIES IS JUST AT THE BEGINNING OF SOMETHING, AND WE'RE DISCOVERING THE TOOLS TO SHAPE OUR OWN DESTINY.

WHO WE BECOME IS UP TO US.

ANNOUNCER: "THE BRAIN WITH DAVID EAGLEMAN" "THE BRAIN WITH DAVID EAGLEMAN" IS AVAILABLE ON DVD.

THE COMPANION BOOK IS ALSO AVAILABLE.

TO ORDER, VISIT SHOPPBS.ORG